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What is a common characteristic of Acanthosis Nigricans?

  1. Presence of rash on the face

  2. Symmetrical hyperpigmented velvety plaque

  3. Formation of blisters on the skin

  4. Acute inflammation of the skin

The correct answer is: Symmetrical hyperpigmented velvety plaque

Acanthosis Nigricans is characterized primarily by the development of symmetrical, hyperpigmented velvety plaques, which often appear in body folds such as the neck, armpits, and groin. This condition is commonly associated with insulin resistance, and the thickened, darkened skin is a visual manifestation of underlying metabolic issues. The texture of the plaques often feels velvety, distinguishing it from other skin conditions that may present with a different texture or coloration. The symmetrical nature of the lesions is also a key feature, as they are usually found on both sides of the body in similar locations, further solidifying the diagnosis. In contrast, the presence of a rash on the face, formation of blisters, and acute inflammation would indicate other dermatological conditions, none of which align with the hallmark signs of Acanthosis Nigricans. Understanding these distinguishing characteristics is crucial for proper assessment and management of patients presenting with this condition.